Your body follows a finely tuned 24-hour rhythm that controls almost all biological processes. This circadian rhythm – from the Latin 'circa diem', meaning about a day – regulates sleep, the hormonal system, body temperature, digestion, and immune function. When you fly to a different time zone, this precise clockwork gets thrown off.
The problem: While you can circle half the globe in just a few hours, your internal clock takes significantly longer to adjust. It's primarily regulated by light – and this signal changes abruptly from one day to the next. The result is the discrepancy we experience as jet lag.
The master clock in the brain
Located in the hypothalamus, a small region in the brain, is the suprachiasmatic nucleus (SCN) – your biological master clock. This tiny cluster of cells receives light signals directly from the retina and then synchronizes all the subordinate clocks in the body. Virtually every organ has its own peripheral clocks that follow the SCN.
When changing time zones, the SCN receives new light signals that no longer match the body's previous rhythms. It begins to adjust – but the peripheral clocks in the liver, muscles, digestive tract, and other organs lag behind. This internal desynchronization causes the typical jet lag symptoms.
Why jet lag is worse in one direction
Adjusting eastward—when you 'lose time'—is more difficult for most people than adjusting westward. The reason: The human natural rhythm is slightly longer than 24 hours. Traveling westward 'lengthens' the day, which aligns with our natural tendency. Traveling eastward shortens it, which works against our natural rhythm.
As a general rule, you need about 1.5 days per time zone for full adjustment when traveling east, and about one day when traveling west. So, on a trip from Europe to New York (6 time zones), you can expect it to take about a week for your rhythm to stabilize again – without any targeted interventions.
The symptoms of a desynchronized body
Jet lag manifests itself on many levels. Sleep disturbances are the most obvious symptom – you're tired when everyone else is awake and wide awake when it's bedtime. But digestive problems, difficulty concentrating, mood swings, general malaise, and even increased susceptibility to infections are also part of the picture.
The intensity varies from person to person. Older people often have more difficulty adjusting than younger people. Early risers ("larks") cope better with travel to the east, night owls with travel to the west. Sleep quality before the trip and general health also play a role.


